Analgesics and Non-Steroidal Anti-Inflamatory Drugs (NSAID) on Raptor™ Biphenyl by LC-MS/MS

PeakstR (min)Conc.
(ng/mL)
Precursor IonProduct IonProduct IonESI Polarity
1.Acetaminophen1.19100152.293.065.0Positive
2.Tenoxicam2.26100338.1121.095.0Positive
3.Etoricoxib2.84100359.2280.0279.2Positive
4.Lornoxicam3.08200373.1121.195.0Positive
5.Ketorolac3.22100256.1104.977.0Positive
6.Piroxicam3.26100332.195.278.1Positive
7.Loxoprofen3.41100245.083.280.9Negative
8.Tolmetin3.64100258.1119.191.0Positive
9.Sulindac3.83100357.2233.1248.0Positive
10.Ketoprofen4.00100253.0209.0--Negative
11.Naproxen4.05200229.0168.9184.9Negative
12.Salsalate4.05100256.8136.892.9Negative
13.Meloxicam4.22100352.1115.0141.0Positive
14.Etodolac4.80100286.0241.9212.0Negative
15.Fenoprofen4.84200240.992.8--Negative
16.Oxaprozin4.86200292.0219.8102.0Negative
17.Ibuprofen4.92200205.0160.9--Negative
18.Flurbiprofen4.99100243.0199.0196.8Negative
19.Parecoxib5.20200371.2234.0165.1Positive
20.Nabumetone5.23100229.1171.1128.1Positive
21.Diclofenac5.46100293.9249.8--Negative
22.Indomethacin5.60100356.0311.8296.9Negative
23.Flufenamic acid5.75100279.9236.1176.2Negative
24.Celecoxib5.90200382.2362.0300.1Positive
25.Mefenamic acid5.91100242.1224.1--Positive
26.Tolfenamic acid6.21100259.9215.8--Negative
27.Meclofenamic acid6.29200293.9257.8177.7Negative
image
LC_CF0620
ColumnRaptor™ Biphenyl (cat.# 9309A12)
Dimensions:100 mm x 2.1 mm ID
Particle Size:2.7 µm
Guard Column:Raptor™ Biphenyl EXP® guard column cartridge 5 mm, 2.1 mm ID, 2.7 µm (cat.# 9309A0252)
Temp.:30 °C
Sample
Diluent:Water
Inj. Vol.:5 µL
Mobile Phase
A:Water + 0.1% formic acid + 5 mM ammonium formate
B: (95:5) Acetonitrile:water + 0.1% formic acid + 5 mM ammonium formate
Time (min)Flow (mL/min)%A%B
0.000.6955
1.000.67030
6.500.64060
6.510.6955
8.500.6955
DetectorMS/MS
Ion Mode:ESI+/ESI-
Mode:Scheduled MRM
InstrumentUHPLC
Notes1. Positive and negative polarity was collected simultaneously from a single injection.
2. Oxaprozin displays enhanced sensitivity using positive polarity.
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