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Analysis of Nicotine and Impurities in Electronic Cigarette Solutions and Vapor

Despite the growing popularity of electronic cigarettes, relatively little work has been done to characterize their vapor. In this study, we developed a quick, simple thermal desorption device for sampling vapor, as well as methods for analyzing vapor and solutions to determine nicotine content (GC-FID) and impurity profiles (GC-MS). This novel approach, which utilizes an Rtx-VMS column, provides detectable levels of volatile organic compounds (VOCs) and semivolatile organic compounds (SVOCs) from a single 40 mL puff.